Molecular Chaperones
Molecular Chaperones are diverse group of protein molecules that control conformational changes in native protein to make it as biologically functional protein . Main role of molecular chaperones Prevent protein degradation Protein folding assistance Prevent aggregation of proteins Prevent prion formation Assistance of translocation of other molecules Types of Chaperones 1.HSP(Heat shock proteins) Proteins which help to assist stressful conditions (elevated temperature, toxic chemical, radiation)in cell. Eg: Eukaryotes Prokaryotes: HSP-10 GroES HSP-40 DNA J HSP-60 GroEL HSP-70 DNA K 2.Lectin Chaperones CALNEXIN CALRETICULIN 3. GRP-58(Glucose Regulated Protein) assist glycoprotein folding 4. Protein