TrEMBL - Translated EMBL

 TrEMBL - Translated EMBL

Translated EMBL was created in 1996 as a computer annotated supplement to Swiss-Prot. It contains translations of all coding sequences in the EMBL nucleotide sequence database. The sequence data are mainly derived from TrEMBL, a database of translated nucleic acid sequences stored in the EMBL database. The annotation of each entry is carefully curated by human experts and thus is of good quality. The protein annotation includes function, domain structure, catalytic sites, cofactor binding, posttranslational modification, metabolic pathway information, disease association, and similarity with other sequences. Much of this information is obtained from scientific literature and entered by database curators. The annotation provides significant added value to each original sequence record. The data record also provides cross referencing links to other online resources of interest. Other features such as very low redundancy and high level of integration with other primary and secondary databases make SWISS-PROT very popular among biologists.A recent effort to combine SWISS-PROT, TrEMBL, and PIR led to the creation of the UniProt database, which has larger coverage than any one of the three databases while at the same time maintaining the original SWISS-PROT feature of low redundancy, cross-references, and a high quality of annotation.

SP-TrEMBL contains entries that will be incorporated into Swiss-Prot. REM-TrEMBL contains entries that are not destined to be included in Swiss-Prot, (for example, T-cell receptors, patented sequences). The entries in REM-TrEMBL have no accession number.

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