CATH

 

CATH

Aim

To retrieve the structural neighbourhood of given protein

Description

CATH classifies protein based on the automates structural alignment program SSAP as well as manual comparison. Structural domain seperations is carried out also as a combined effect of a human expert and computer programs. Individual domain structures are classified at five major level, class, architecture, fold/topology, homologous superfamily and homologous family. The definition for class is CATH similar to SCOP and is based on secondary structure content. Architecture is a unique level in CATH, intermediate between fold and class. It describes overall packing and arrangement of secondary structure. The topology level is equivalent to the fold level in SCOP,which describes overall orientation of the secondary structure and take into account the sequence connectively between secondary element. The homologous superfamily and homologous family are equivalent to the superfamily and family level I SCOP.

 

Procedure

STEP 1: Access http://www.cathdb.info/

STEP 2: Type the protein of interest or PDB ID  and click search

STEP 3: Select any one of the hit from CATH Domain.

STEP 5: Note down the CATH classification and super family.

STEP 6: Note down structural neighbourhood of given hit.

STEP 7: Save the page.

Result

Structural neighbourhood of the given protein was retrieved.            


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